BioPharmaceutical
With increased concern about sustainability, environment and green technology, the chemical synthesis is shifting to microbial or biopharmaceutical space. There are many diverse sectors in industrial biotechnology umbrella which includes biopharmaceuticals, bio services, bio agriculture, bioindustry, and bioinformatics. This sector is thus gaining momentum and growing at a significant rate nearing 30%. With more than thirty years of experience, Sanitech Engineers is prepared to offer cutting-edge technology and solutions that will enable the Biopharmaceutical business to keep up with its expansion by boosting output in an economical way.
Insulin Purification
Insulin plays a crucial role in human metabolism and it’s structural properties of folding, self-assembling and receptor binding makes it a very precise molecule in the treatment of Diabetes. Insulin is a biosynthetic product and it has a very controlled bio-manufacturing process. At multiple steps or unit operations separation, purification and concentration activities are to be performed for achieving active insulin molecule with high recovery.
Modern HPLC (High-Performance Liquid Chromatography) and LPLC (Low-Pressure Liquid Chromatography) systems from Sanitech Engineers are at the forefront of insulin purification, allowing producers to meet the strictest regulatory standards and provide patients worldwide with life-saving drugs.
FAQs
Insulin is purified after biosynthesis through a series of downstream processing steps designed to achieve very high purity. These steps typically include chromatography techniques such as HPLC, preparative chromatography, and low-pressure liquid chromatography (LPLC), along with membrane filtration for concentration and buffer exchange. The process removes host cell proteins, process impurities, and variants to meet strict biopharmaceutical quality and regulatory standards.
Plasma Fractionation
Saving a life is an ultimate activity and plasma fractionation is one the most essential biotechnological approach to make life-saving therapeutic proteins. For such an important lifesaving product it is prime important to have a sustainable technology. Apart from this, the equipment or system is crucial which should be installed in a GMP facility. The footprint wrt the facility available also matters in decision making.
With more than 3.5 decades of manufacturing expertise, our state-of-the-art products, such as TFF (Tangential Flow Filtration) and Preparative Chromatography systems, are made to outperform traditional techniques in terms of efficiency, cost-effectiveness, and smooth automation.
You can expect increased productivity and more efficient operations with our TFF cassettes. By ensuring continuous processing, the Tangential Flow Filtration system reduces downtime and increases yield. For the chromatographic separation of plasma components, our DAC LPLC (Low-Pressure Liquid Chromatography), Static MPLC (Medium Pressure Liquid Chromatography), and LPLC (Low-Pressure Liquid Chromatograph) columns are painstakingly designed to provide outstanding purity and yield.
FAQs
Plasma fractionation is the separation of human blood plasma into its individual protein components using controlled physical and chemical methods. The process commonly involves filtration, precipitation, and chromatography to isolate therapeutic proteins such as albumin, immunoglobulins, and clotting factors for medical use.
Fractionated plasma refers to plasma that has been separated into distinct protein fractions, each enriched with specific proteins. These fractions are further purified and formulated into life-saving biopharmaceutical products.
Plasma is separated from whole blood using a plasmapheresis machine, which removes plasma while returning red blood cells and other components to the donor. Downstream purification of plasma proteins is then carried out using filtration and chromatography systems.
Recombinant proteins
Sanitech Engineers specializes in manufacturing innovative systems for the purification of recombinant proteins. Our state-of-the-art technology makes use of membrane systems for Tangential Flow Filtration (TFF) and Preparative Chromatography.By attaching target proteins to a stationary phase, removing contaminants, and eluting the pure protein, preparative chromatography uses concepts like affinity, ion exchange, and size exclusion to separate target proteins from complex mixtures.
Proteins are concentrated and purified based on size and molecular weight using Tangential Flow Filtration membrane systems, which are based on pressure-driven filtration. Sanitech Engineers has the capacity and know-how to create solutions that are specifically tailored to your needs and products.
FAQs
A recombinant protein is a protein produced using genetically engineered host cells (such as bacteria, yeast, or mammalian cells) into which the gene encoding the desired protein has been inserted. This technology enables large-scale, controlled production of therapeutic proteins.
Recombinant proteins are widely used in biopharmaceuticals as therapeutic hormones, enzymes, vaccines, growth factors, and antibodies. Common applications include treatments for diabetes, cancer, autoimmune diseases, infections, and rare genetic disorders.
Purification of mAbs and Vaccines
Sanitech Engineers has created sophisticated chromatography systems that are excellent for vaccine purification as well as intermediate purification and polishing of protein solutions containing vital biomolecules like albumin, lgG, lgM, mAbs, and hormones. These state-of-the-art systems offer many benefits, such as increased production capacity, reduced space needs, and easier cleaning and maintenance procedures.
Our Preparative Chromatography systems provide the pharmaceutical and biotech sectors with increased productivity and cost-effectiveness while guaranteeing the best possible purification of monoclonal antibodies and vaccines by effectively handling a broad variety of biomolecules.
FAQs
Purification of monoclonal antibodies and vaccines is essential to remove host cell proteins, DNA, endotoxins, and process impurities. High-purity mAbs and vaccines are critical for ensuring patient safety, product efficacy, and regulatory compliance in biopharmaceutical manufacturing.
Biopharmaceutical purification typically uses a combination of:
Preparative chromatography systems (Protein A, ion exchange, polishing steps)
Tangential flow filtration (TFF) systems for concentration and diafiltration
These technologies enable scalable, reproducible, and GMP-compliant purification processes.
Extraction from fermentation broth
Fermentation is one of the quickest and easiest also green process to manufacture value added products using microorganisms. All attempts are made to maximally produce it. But the efforts go vain if the produce molecule is not extracted or separated from biomass to the fullest.
Sanitech Engineers have built themselves as one of the successful membrane filtration system manufacturers having global standards. They have the entire membrane filtration spectrum.
Further they have collaborated with SFE Process, France for supercritical fluid process which uses supercritical CO2 for extraction and purification of desired molecules.
Sanitech Engineers offers the equipment and know-how to satisfy your needs, whether you need to concentrate, purify, or clarify precious substances. Their team of professionals can offer specialised solutions made to fit your particular requirements, guaranteeing successful and economical procedures.
FAQs
Extractive fermentation refers to the recovery and separation of valuable biomolecules directly from fermentation broth. The process uses membrane filtration technologies to clarify, concentrate, and partially purify target products such as proteins, enzymes, or peptides before downstream purification.
Specialized bioprocess equipment manufacturers provide systems for extraction from fermentation broth, including microfiltration, ultrafiltration, nanofiltration, and reverse osmosis systems. These systems are designed to handle complex biological feeds and support scale-up from lab to commercial production.
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